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KCNN1 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP17223b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP17223b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
KCNN1 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q92952 |
| Other Accession | NP_002239.2 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 59987 Da |
KCNN1 Antibody (C-term) - Additional info | |
| Gene ID 3780 | |
| Other Names KCNN1; SK; Small conductance calcium-activated potassium channel protein 1; KCa2.1 | |
| Target/Specificity This KCNN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-419 amino acids from the C-terminal region of human KCNN1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions KCNN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
KCNN1 Antibody (C-term) - Protein Information | |
| Name KCNN1 | |
| Synonyms SK | |
| Function Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity) | |
| Cellular Location Membrane; Multi-pass membrane protein. | |
KCNN1 Antibody (C-term) - Related products
KCNN1 Antibody (C-term) - Application data
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KCNN1 Antibody (C-term) (Cat. #AP17223b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the KCNN1 antibody detected the KCNN1 protein (arrow).
KCNN1 Antibody (C-term) - Research Areas
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BACKGROUND
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes.
REFERENCES
Wu, C., et al. Proteomics 7(11):1775-1785(2007) Wei, A.D., et al. Pharmacol. Rev. 57(4):463-472(2005) Arnold, S.J., et al. Neuroreport 14(2):191-195(2003) Boettger, M.K., et al. Brain 125 (PT 2), 252-263 (2002) : Zhang, B.M., et al. Biochemistry 40(10):3189-3195(2001)
