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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   KCNN1 Antibody (C-term)   

KCNN1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KCNN1 Antibody (C-term) AP17223b
    KCNN1 Antibody (C-term) (Cat. #AP17223b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the KCNN1 antibody detected the KCNN1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92952
Other Accession NP_002239.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 59987 Da
Antigen Region 391-419 aa
Additional Information
Gene ID 3780
Other Names Small conductance calcium-activated potassium channel protein 1, SK1, SKCa 1, SKCa1, KCa21, KCNN1, SK
Target/Specificity This KCNN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the C-terminal region of human KCNN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCNN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNN1
Synonyms SK
Function Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
Cellular Location Membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes.


Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Wei, A.D., et al. Pharmacol. Rev. 57(4):463-472(2005)
Arnold, S.J., et al. Neuroreport 14(2):191-195(2003)
Boettger, M.K., et al. Brain 125 (PT 2), 252-263 (2002) :
Zhang, B.M., et al. Biochemistry 40(10):3189-3195(2001)

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$ 295.00
$ 99.00
Cat# AP17223b
(40 western blots)
Availability: In Stock
Bulk Size
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