|Application ||WB, E|
|Other Accession||Q6PCF7, Q3B7D1, Q3UE37, NP_075567.2|
|Predicted||Mouse, Rat, Xenopus|
|Calculated MW||38210 Da|
|Antigen Region||284-310 aa|
|Other Names||Ubiquitin-conjugating enzyme E2 Z, Uba6-specific E2 conjugating enzyme 1, Use1, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z, UBE2Z|
|Target/Specificity||This UBE2Z antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-310 amino acids from the C-terminal region of human UBE2Z.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UBE2Z Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed. Highly in placenta, pancreas, spleen and testis.|
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Provided below are standard protocols that you may find useful for product applications.
Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE2Z is an E2 enzyme (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM].
Gu, X., et al. Mol. Biol. Rep. 34(3):183-188(2007)
Jin, J., et al. Nature 447(7148):1135-1138(2007)
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