|Application ||WB, E|
|Other Accession||Q6PCF7, Q3B7D1, Q3UE37, NP_075567.2|
|Predicted||Mouse, Rat, Xenopus|
|Calculated MW||38210 Da|
|Antigen Region||284-310 aa|
|Other Names||Ubiquitin-conjugating enzyme E2 Z, Uba6-specific E2 conjugating enzyme 1, Use1, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z, UBE2Z|
|Target/Specificity||This UBE2Z antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-310 amino acids from the C-terminal region of human UBE2Z.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UBE2Z Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed. Highly in placenta, pancreas, spleen and testis.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE2Z is an E2 enzyme (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM].
Gu, X., et al. Mol. Biol. Rep. 34(3):183-188(2007)
Jin, J., et al. Nature 447(7148):1135-1138(2007)
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