|Application ||WB, E|
|Other Accession||P49655, Q9JM63, NP_002232.2|
|Calculated MW||42508 Da|
|Antigen Region||203-230 aa|
|Other Names||ATP-sensitive inward rectifier potassium channel 10, ATP-dependent inwardly rectifying potassium channel Kir41, Inward rectifier K(+) channel Kir12, Potassium channel, inwardly rectifying subfamily J member 10, KCNJ10|
|Target/Specificity||This KCNJ10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-230 amino acids from the Central region of human KCNJ10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNJ10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.|
|Cellular Location||Membrane; Multi-pass membrane protein. Basolateral cell membrane. Note=In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.|
|Tissue Location||Expressed in kidney (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.
Jonard, L., et al. Int. J. Pediatr. Otorhinolaryngol. 74(9):1049-1053(2010)
Reichold, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14490-14495(2010)
Heuser, K., et al. Epilepsy Res. 88(1):55-64(2010)
Pawelczyk, M., et al. Ann. Hum. Genet. 73 (PT 4), 411-421 (2009) :
Yang, T., et al. Am. J. Hum. Genet. 84(5):651-657(2009)
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