|Application ||WB, E|
|Calculated MW||47092 Da|
|Antigen Region||254-282 aa|
|Other Names||Alpha-1, 3/1, 6-mannosyltransferase ALG2, Asparagine-linked glycosylation protein 2 homolog, GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1, 3-mannosyltransferase, GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase, GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1, 6-mannosyltransferase, ALG2|
|Target/Specificity||This ALG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-282 amino acids from the Central region of human ALG2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALG2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate.|
|Cellular Location||Membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants.
Inuzuka, T., et al. BMC Struct. Biol. 10, 25 (2010) :
Okumura, M., et al. Biochem. Biophys. Res. Commun. 386(1):237-241(2009)
Hoj, B.R., et al. Biochem. Biophys. Res. Commun. 378(1):145-148(2009)
Mahul-Mellier, A.L., et al. J. Biol. Chem. 283(50):34954-34965(2008)
la Cour, J.M., et al. Mol Oncol 1(4):431-439(2008)
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