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TROVE2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P10155 |
| Other Accession | O08848, NP_001035828.1, NP_001166995.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60671 Da |
| Antigen Region | 467-495 aa |
| Gene ID | 6738 |
|---|---|
| Other Names | 60 kDa SS-A/Ro ribonucleoprotein, 60 kDa Ro protein, 60 kDa ribonucleoprotein Ro, RoRNP, Ro 60 kDa autoantigen, Sjoegren syndrome antigen A2, Sjoegren syndrome type A antigen, SS-A, TROVE domain family member 2, TROVE2, RO60, SSA2 |
| Target/Specificity | This TROVE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467-495 amino acids from the C-terminal region of human TROVE2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TROVE2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RO60 (HGNC:11313) |
|---|---|
| Function | RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853). Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853). May play roles in cilia formation and/or maintenance (By similarity). |
| Cellular Location | Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation.
References
Reed, J.H., et al. Arthritis Rheum. 62(5):1448-1456(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Clancy, R.M., et al. J. Immunol. 184(4):2148-2155(2010)
Reed, J.H., et al. Arthritis Rheum. 60(3):860-869(2009)
Barcellos, K.S., et al. J. Rheumatol. 34(6):1283-1292(2007)
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