|Application ||WB, E|
|Other Accession||Q3MHX6, NP_001017958.1, NP_006803.1|
|Calculated MW||75562 Da|
|Antigen Region||521-549 aa|
|Other Names||Protein OS-9, Amplified in osteosarcoma 9, OS9|
|Target/Specificity||This OS9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the C-terminal region of human OS9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OS9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines Isoform 2 is the major isoform detected in all cell types examined|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Feng, T., et al. Hum. Genet. 128(3):269-280(2010)
Mikami, K., et al. Glycobiology 20(3):310-321(2010)
Hosokawa, N., et al. J. Biol. Chem. 284(25):17061-17068(2009)
Jansen, B.J., et al. Mol. Immunol. 46(4):505-515(2009)
Alcock, F., et al. J. Mol. Biol. 385(4):1032-1042(2009)
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