|Application ||WB, E|
|Calculated MW||85125 Da|
|Antigen Region||92-120 aa|
|Other Names||Kinesin-like protein KIF3B, HH0048, Microtubule plus end-directed kinesin motor 3B, Kinesin-like protein KIF3B, N-terminally processed, KIF3B, KIAA0359|
|Target/Specificity||This KIF3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-120 amino acids from the N-terminal region of human KIF3B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KIF3B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily.
Reed, A.A., et al. Am. J. Physiol. Renal Physiol. 298 (2), F365-F380 (2010) :
Keil, R., et al. J. Cell. Sci. 122 (PT 8), 1174-1183 (2009) :
Schonteich, E., et al. J. Cell. Sci. 121 (PT 22), 3824-3833 (2008) :
Wu, Y., et al. Hum. Mol. Genet. 15(22):3280-3292(2006)
Haraguchi, K., et al. J. Biol. Chem. 281(7):4094-4099(2006)
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