|Application ||WB, E|
|Other Accession||Q63273, Q61626, NP_002079.3|
|Calculated MW||109265 Da|
|Antigen Region||101-129 aa|
|Other Names||Glutamate receptor ionotropic, kainate 5, GluK5, Excitatory amino acid receptor 2, EAA2, Glutamate receptor KA-2, KA2, GRIK5, GRIK2|
|Target/Specificity||This GRIK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-129 amino acids from the N-terminal region of human GRIK5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRIK5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. [provided by RefSeq].
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)
Arai, S., et al. Psychiatr. Genet. 19(1):6-13(2009)
Fotheringham, J., et al. J Neuroimmune Pharmacol 3(2):105-116(2008)
Shibata, H., et al. Psychiatry Res 141(1):39-51(2006)
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