|Application ||WB, E|
|Calculated MW||26833 Da|
|Antigen Region||129-157 aa|
|Other Names||Oligoribonuclease, mitochondrial, 31--, RNA exonuclease 2 homolog, Small fragment nuclease, REXO2, SFN, SMFN|
|Target/Specificity||This REXO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-157 amino acids from the Central region of human REXO2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||REXO2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily =5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.|
|Cellular Location||Isoform 1: Mitochondrion intermembrane space. Mitochondrion matrix Isoform 3: Cytoplasm.|
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Provided below are standard protocols that you may find useful for product applications.
Nucleases are components of DNA and RNA metabolism that carry out functions in DNA repair, replication, and recombination and in RNA processing and degradation. SFN is a homolog of Orn, a 3-prime-to-5-prime exoribonuclease of E. coli that attacks the free 3-prime hydroxyl group on single-stranded RNA, releasing 5-prime mononucleotides in a sequential manner.
Young Park, A., et al. Protein Expr. Purif. 57(2):180-187(2008)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Ito, S., et al. Photochem. Photobiol. 80(2):281-285(2004)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
Nguyen, L.H., et al. J. Biol. Chem. 275(34):25900-25906(2000)
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