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ASB2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96Q27 |
| Other Accession | NP_057234.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 70212 Da |
| Antigen Region | 58-86 aa |
| Gene ID | 51676 |
|---|---|
| Other Names | Ankyrin repeat and SOCS box protein 2, ASB-2, ASB2 |
| Target/Specificity | This ASB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the N-terminal region of human ASB2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ASB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASB2 |
|---|---|
| Function | Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:16325183, PubMed:15590664). Mediates Notch- induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 (PubMed:21119685). Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation (PubMed:32179481). |
| Cellular Location | Cytoplasm, cytoskeleton, stress fiber |
| Tissue Location | [Isoform 1]: Expressed in muscle cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
References
Heuze, M.L., et al. Blood 112(13):5130-5140(2008)
Kohroki, J., et al. FEBS Lett. 579(30):6796-6802(2005)
Heuze, M.L., et al. J. Biol. Chem. 280(7):5468-5474(2005)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
Namciu, S.J., et al. Mamm. Genome 15(3):162-178(2004)
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