|Application ||WB, E|
|Calculated MW||44103 Da|
|Antigen Region||163-191 aa|
|Other Names||Collagen and calcium-binding EGF domain-containing protein 1, Full of fluid protein homolog, CCBE1, KIAA1983|
|Target/Specificity||This CCBE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human CCBE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCBE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.|
|Tissue Location||Not expressed in blood or lymphatic endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Connell, F., et al. Hum. Genet. 127(2):231-241(2010)
Barton, C.A., et al. Br. J. Cancer 102(1):87-96(2010)
Alders, M., et al. Nat. Genet. 41(12):1272-1274(2009)
Hogan, B.M., et al. Nat. Genet. 41(4):396-398(2009)
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