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GBP5 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GBP5 Antibody (N-term) AP17262a
    GBP5 Antibody (N-term) (Cat. #AP17262a) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the GBP5 antibody detected the GBP5 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96PP8
Other Accession NP_443174.1, NP_001127958.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 66617 Da
Antigen Region 140-167 aa
Additional Information
Gene ID 115362
Other Names Guanylate-binding protein 5, GBP-TA antigen, GTP-binding protein 5, GBP-5, Guanine nucleotide-binding protein 5, GBP5
Target/Specificity This GBP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of human GBP5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGBP5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GBP5
Function As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).
Cellular Location Cytoplasm. Golgi apparatus membrane; Lipid- anchor
Tissue Location Expressed in peripheral blood monocytes (at protein level).
Research Areas
Citations (0)

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Background

Belongs to the GBP family.

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Wehner, M., et al. FEBS J. 277(7):1597-1605(2010)
Ito, Y., et al. J. Infect. Dis. 197(5):663-666(2008)
Tripal, P., et al. J. Interferon Cytokine Res. 27(1):44-52(2007)
Fellenberg, F., et al. J. Invest. Dermatol. 122(6):1510-1517(2004)

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Cat# AP17262a
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Quantity:
(40 western blots)
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