|Application ||WB, E|
|Other Accession||NP_443174.1, NP_001127958.1|
|Calculated MW||66617 Da|
|Antigen Region||140-167 aa|
|Other Names||Guanylate-binding protein 5, GBP-TA antigen, GTP-binding protein 5, GBP-5, Guanine nucleotide-binding protein 5, GBP5|
|Target/Specificity||This GBP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of human GBP5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GBP5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Lipid- anchor|
|Tissue Location||Expressed in peripheral blood monocytes (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Belongs to the GBP family.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Wehner, M., et al. FEBS J. 277(7):1597-1605(2010)
Ito, Y., et al. J. Infect. Dis. 197(5):663-666(2008)
Tripal, P., et al. J. Interferon Cytokine Res. 27(1):44-52(2007)
Fellenberg, F., et al. J. Invest. Dermatol. 122(6):1510-1517(2004)
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