SYCP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q15431 |
Other Accession | NP_003167.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 114192 Da |
Antigen Region | 927-955 aa |
Gene ID | 6847 |
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Other Names | Synaptonemal complex protein 1, SCP-1, Cancer/testis antigen 8, CT8, SYCP1, SCP1 |
Target/Specificity | This SYCP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 927-955 amino acids from the C-terminal region of human SYCP1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SYCP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SYCP1 {ECO:0000303|PubMed:29915389, ECO:0000312|HGNC:HGNC:11487} |
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Function | Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q62209}. Chromosome {ECO:0000250|UniProtKB:Q62209}. Chromosome, centromere {ECO:0000250|UniProtKB:Q62209}. Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N- terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (By similarity) {ECO:0000250|UniProtKB:Q03410, ECO:0000250|UniProtKB:Q62209} |
Tissue Location | Testis.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase.
References
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Neumann, F., et al. Blood 106(9):3105-3113(2005)
Costa, Y., et al. J. Cell. Sci. 118 (PT 12), 2755-2762 (2005) :
Eichmuller, S., et al. Proc. Natl. Acad. Sci. U.S.A. 98(2):629-634(2001)
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