|Application ||WB, E|
|Calculated MW||145274 Da|
|Antigen Region||1204-1231 aa|
|Other Names||Contactin-associated protein-like 4, Cell recognition molecule Caspr4, CNTNAP4, CASPR4, KIAA1763|
|Target/Specificity||This CNTNAP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1204-1231 amino acids from the C-terminal region of human CNTNAP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNTNAP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity).|
|Cellular Location||Cell junction, synapse, presynaptic cell membrane; Single-pass type I membrane protein. Note=Specifically present within the presynaptic compartment of synapses.|
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Provided below are standard protocols that you may find useful for product applications.
This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :
Nordgard, S.H., et al. Genes Chromosomes Cancer 47(8):680-696(2008)
Kim, J.M., et al. DNA Res. 13(6):275-286(2006)
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