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CNTNAP4 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CNTNAP4 Antibody (C-term) AP17276b
    CNTNAP4 Antibody (C-term) (Cat. #AP17276b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the CNTNAP4 antibody detected the CNTNAP4 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9C0A0
Other Accession NP_207837.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 145274 Da
Antigen Region 1204-1231 aa
Additional Information
Gene ID 85445
Other Names Contactin-associated protein-like 4, Cell recognition molecule Caspr4, CNTNAP4, CASPR4, KIAA1763
Target/Specificity This CNTNAP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1204-1231 amino acids from the C-terminal region of human CNTNAP4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCNTNAP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNTNAP4
Synonyms CASPR4, KIAA1763
Function Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity).
Cellular Location Presynaptic cell membrane {ECO:0000250|UniProtKB:Q99P47}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q99P47}. Note=Specifically present within the presynaptic compartment of synapses. {ECO:0000250|UniProtKB:Q99P47}
Research Areas
Citations (0)
citation

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Background

This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :
Nordgard, S.H., et al. Genes Chromosomes Cancer 47(8):680-696(2008)
Kim, J.M., et al. DNA Res. 13(6):275-286(2006)

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$ 365.00
$ 140.00
Cat# AP17276b
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