|Application ||IF, WB, E|
|Other Accession||Q8R3L2, NP_055787.1|
|Calculated MW||76667 Da|
|Antigen Region||186-215 aa|
|Other Names||Transcription factor 25, TCF-25, Nuclear localized protein 1, TCF25, KIAA1049, NULP1|
|Target/Specificity||This TCF25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 amino acids from the N-terminal region of human TCF25.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TCF25 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.|
|Cellular Location||Nucleus. Note=Some staining in the cytosol|
|Tissue Location||In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.|
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Provided below are standard protocols that you may find useful for product applications.
TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM].
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Steen, H., et al. Biochem. Biophys. Res. Commun. 366(2):432-437(2008)
Cai, Z., et al. Biochem. Biophys. Res. Commun. 343(3):973-981(2006)
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