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PLEKHG5 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PLEKHG5 Antibody (N-term) AP17282a
    PLEKHG5 Antibody (N-term) (Cat. #AP17282a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PLEKHG5 antibody detected the PLEKHG5 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O94827
Other Accession Q6RFZ7, Q66T02, NP_001036128.1, NP_001036129.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 117451 Da
Antigen Region 175-202 aa
Additional Information
Gene ID 57449
Other Names Pleckstrin homology domain-containing family G member 5, PH domain-containing family G member 5, Guanine nucleotide exchange factor 720, GEF720, PLEKHG5, KIAA0720
Target/Specificity This PLEKHG5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-202 amino acids from the N-terminal region of human PLEKHG5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLEKHG5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0720
Function Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis.
Cellular Location Cytoplasm. Cytoplasm, perinuclear region. Cell junction Cell projection, lamellipodium. Note=Predominantly cytoplasmic, however when cells are stimulated found in perinuclear regions. Localized at cell-cell junctions in quiescent endothelial cells, it relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (By similarity).
Tissue Location Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines.
Research Areas
Citations (0)

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This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Multations in this gene have been found in a family with distal spinal muscular atrophy.


Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Newton-Cheh, C., et al. Nat. Genet. 41(4):399-406(2009)
Maystadt, I., et al. Am. J. Hum. Genet. 81(1):67-76(2007)
Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003) :
Matsuda, A., et al. Oncogene 22(21):3307-3318(2003)

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Cat# AP17282a
(40 western blots)
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