|Application ||WB, E|
|Other Accession||Q4FZT2, Q8BVQ5, Q58DN4, NP_057231.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||42315 Da|
|Antigen Region||351-379 aa|
|Other Names||Protein phosphatase methylesterase 1, PME-1, PPME1, PME1|
|Target/Specificity||This PPME1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-379 amino acids from the C-terminal region of human PPME1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPME1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Protein phosphatase methylesterase-1 catalyzes the demethylation of the protein phosphatase-2A catalytic subunit (PPP2CA; MIM 176915) (Ogris et al., 1999 [PubMed 10318862]).
Puustinen, P., et al. Cancer Res. 69(7):2870-2877(2009)
Longin, S., et al. Exp. Cell Res. 314(1):68-81(2008)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Ogris, E., et al. J. Biol. Chem. 274(20):14382-14391(1999)
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