PPME1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9Y570 |
Other Accession | Q4FZT2, Q8BVQ5, Q58DN4, NP_057231.1 |
Reactivity | Human |
Predicted | Bovine, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42315 Da |
Antigen Region | 351-379 aa |
Gene ID | 51400 |
---|---|
Other Names | Protein phosphatase methylesterase 1, PME-1, PPME1, PME1 |
Target/Specificity | This PPME1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-379 amino acids from the C-terminal region of human PPME1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PPME1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PPME1 |
---|---|
Synonyms | PME1 |
Function | Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Protein phosphatase methylesterase-1 catalyzes the demethylation of the protein phosphatase-2A catalytic subunit (PPP2CA; MIM 176915) (Ogris et al., 1999 [PubMed 10318862]).
References
Puustinen, P., et al. Cancer Res. 69(7):2870-2877(2009)
Longin, S., et al. Exp. Cell Res. 314(1):68-81(2008)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Ogris, E., et al. J. Biol. Chem. 274(20):14382-14391(1999)
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