|Application ||WB, E|
|Other Accession||Q4FZT2, Q8BVQ5, Q58DN4, NP_057231.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||42315 Da|
|Antigen Region||351-379 aa|
|Other Names||Protein phosphatase methylesterase 1, PME-1, PPME1, PME1|
|Target/Specificity||This PPME1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-379 amino acids from the C-terminal region of human PPME1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPME1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.|
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Provided below are standard protocols that you may find useful for product applications.
Protein phosphatase methylesterase-1 catalyzes the demethylation of the protein phosphatase-2A catalytic subunit (PPP2CA; MIM 176915) (Ogris et al., 1999 [PubMed 10318862]).
Puustinen, P., et al. Cancer Res. 69(7):2870-2877(2009)
Longin, S., et al. Exp. Cell Res. 314(1):68-81(2008)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Ogris, E., et al. J. Biol. Chem. 274(20):14382-14391(1999)
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