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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   NELF Antibody (C-term)   

NELF Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NELF Antibody (C-term) AP17290B
    NELF Antibody (C-term) (Cat. #AP17290b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the NELF antibody detected the NELF protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6X4W1
Other Accession Q9EPI6, Q99NF2, NP_001124442.1, NP_001124441.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 60143 Da
Antigen Region 501-530 aa
Additional Information
Gene ID 26012
Other Names NMDA receptor synaptonuclear signaling and neuronal migration factor, Nasal embryonic luteinizing hormone-releasing hormone factor, Nasal embryonic LHRH factor, NSMF, NELF
Target/Specificity This NELF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 501-530 amino acids from the C-terminal region of human NELF.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNELF Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NELF
Function Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.
Cellular Location Nucleus. Nucleus envelope. Nucleus membrane Nucleus matrix. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Membrane. Note=Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium Associates with transcriptionally active chromatin regions Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor-dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in a importin-dependent manner (By similarity).
Tissue Location Highly expressed in adult and fetal brain. Weakly expressed in heart, liver, spleen, testis, small intestine, skeletal muscle, peripheral white blood cells and kidney
Research Areas
Citations (0)

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The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene.


Xu, N., et al. Mol. Cell. Endocrinol. 319 (1-2), 47-55 (2010) :
Trarbach, E.B., et al. Clin. Endocrinol. (Oxf) 72(3):371-376(2010)
Yung, T.M., et al. Exp. Cell Res. 315(10):1693-1705(2009)
Pedersen-White, J.R., et al. Mol. Hum. Reprod. 14(6):367-370(2008)
Lim, J., et al. Cell 125(4):801-814(2006)

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$ 295.00
$ 99.00
Cat# AP17290B
(40 western blots)
Availability: In Stock
Bulk Size
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