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OCT4 Antibody (Center S236)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP17298c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP17298c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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OCT4 Antibody (Center S236) - Product info | |
| Application | WB
|
| Primary Accession | Q01860 |
| Other Accession | Q9TSV5, P20263, O97552, Q06416, NP_002692.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Pig |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 38571 Da |
OCT4 Antibody (Center S236) - Additional info | |
| Gene ID 5460 | |
| Other Names POU5F1; OCT3; OCT4; OTF3; POU domain, class 5, transcription factor 1; Octamer-binding protein 3; Octamer-binding protein 4; Octamer-binding transcription factor 3 | |
| Target/Specificity This OCT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-242 amino acids from the Central region of human OCT4. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions OCT4 Antibody (Center S236) is for research use only and not for use in diagnostic or therapeutic procedures. | |
OCT4 Antibody (Center S236) - Protein Information | |
| Name POU5F1 | |
| Synonyms OCT3, OCT4, OTF3 | |
| Function Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency | |
| Cellular Location Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern | |
| Tissue Location Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues | |
OCT4 Antibody (Center S236) - Related products
AM1967a: POU5F1 Antibody (Ascites)
AP11546a: OCT3/4 Antibody (C279)
AP17298c: OCT4 Antibody (Center S236)
AP2046a: OCT4 (OCT3) Antibody (N-term)
AP2046c: OCT4 (OCT3) Antibody (E125)
AP3724a: Phospho-OCT4- S236 Antibody
RI14131: POU5F1 predesign siRNA
BP2046a: OCT3 (OCT4) Antibody (N-term) Blocking Peptide
BP2046c: OCT3/4 Antibody (E125) Blocking Peptide
BP2046d: OCT3/4 Antibody (S136) Blocking Peptide
OCT4 Antibody (Center S236) - Application data
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OCT4 Antibody (pS236) (Cat. #AP17298c) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the OCT4 antibody detected the OCT4 protein (arrow).
OCT4 Antibody (Center S236) - Research Areas
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BACKGROUND
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
REFERENCES
Abu-Remaileh, M., et al. EMBO J. 29(19):3236-3248(2010) Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010) Schultz, S.S., et al. Mol. Cell. Biol. 30(18):4521-4534(2010) Kim, S., et al. Br. J. Cancer 102(2):436-446(2010) Wang, X., et al. Stem Cells 27(6):1265-1275(2009)
