|Application ||WB, E|
|Other Accession||Q9JIT0, NP_071903.2|
|Calculated MW||55098 Da|
|Antigen Region||262-290 aa|
|Other Names||Limb region 1 protein homolog, Differentiation-related gene 14 protein, LMBR1, C7orf2, DIF14|
|Target/Specificity||This LMBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the Central region of human LMBR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LMBR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative membrane receptor.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed with strongest expression in heart and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Farooq, M., et al. Eur. J. Hum. Genet. 18(6):733-736(2010)
Rutsch, F., et al. Nat. Genet. 41(2):234-239(2009)
He, F., et al. PLoS ONE 3 (8), E2948 (2008) :
Wang, Z.Q., et al. Biochem. Biophys. Res. Commun. 355(2):312-317(2007)
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