|Application ||WB, E|
|Calculated MW||60320 Da|
|Antigen Region||433-460 aa|
|Other Names||STE20/SPS1-related proline-alanine-rich protein kinase, Ste-20-related kinase, Serine/threonine-protein kinase 39, Stk39, Spak|
|Target/Specificity||This Mouse Stk39 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 433-460 amino acids from the C-terminal region of mouse Stk39.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Stk39 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (PubMed:21317537, PubMed:23542070).|
|Cellular Location||Cytoplasm. Nucleus. Note=Nucleus when caspase-cleaved.|
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Provided below are standard protocols that you may find useful for product applications.
Stk39 may act as a mediator of stress-activated signals.
Yang, S.S., et al. J. Am. Soc. Nephrol. 21(11):1868-1877(2010)
Gagnon, K.B., et al. Am. J. Physiol., Cell Physiol. 299 (3), C614-C620 (2010) :
Sid, B., et al. J. Physiol. (Lond.) 588 (PT 13), 2315-2328 (2010) :
Reiche, J., et al. Mol. Cell. Biol. 30(12):3027-3037(2010)
Hengl, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(13):6052-6057(2010)
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