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Mouse Stk39 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Z1W9 |
| Other Accession | NP_058562.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60320 Da |
| Antigen Region | 433-460 aa |
| Gene ID | 53416 |
|---|---|
| Other Names | STE20/SPS1-related proline-alanine-rich protein kinase, Ste-20-related kinase, Serine/threonine-protein kinase 39, Stk39, Spak |
| Target/Specificity | This Mouse Stk39 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 433-460 amino acids from the C-terminal region of mouse Stk39. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Stk39 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Stk39 |
|---|---|
| Synonyms | Spak |
| Function | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Specifically recognizes and binds proteins with a RFXV motif (PubMed:14563843). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:14563843, PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (By similarity). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (By similarity). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (PubMed:21317537, PubMed:23542070). Phosphorylates RELT (PubMed:16530727). |
| Cellular Location | Cytoplasm. Nucleus. Note=Nucleus when caspase-cleaved. |
| Tissue Location | Expressed in the kidney, including in epithelial cells of the thick ascending limb of Henle's loop and in the distal convoluted tubule (at protein level). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Stk39 may act as a mediator of stress-activated signals.
References
Yang, S.S., et al. J. Am. Soc. Nephrol. 21(11):1868-1877(2010)
Gagnon, K.B., et al. Am. J. Physiol., Cell Physiol. 299 (3), C614-C620 (2010) :
Sid, B., et al. J. Physiol. (Lond.) 588 (PT 13), 2315-2328 (2010) :
Reiche, J., et al. Mol. Cell. Biol. 30(12):3027-3037(2010)
Hengl, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(13):6052-6057(2010)
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$ 365.00
$ 140.00
Cat# AP17317b
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