|Application ||WB, E|
|Calculated MW||105336 Da|
|Antigen Region||257-284 aa|
|Other Names||Serine/threonine-protein kinase TAO3, Thousand and one amino acid protein 3, Taok3|
|Target/Specificity||This Mouse Taok3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-284 amino acids from the N-terminal region of mouse Taok3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Taok3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity).|
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Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK (By similarity).
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
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