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Mouse Tlk1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Tlk1 Antibody (C-term) AP17323B
    Mouse Tlk1 Antibody (C-term) (Cat. #AP17323b) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Tlk1 antibody detected the Tlk1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8C0V0
Other Accession Q9UKI8, NP_766252.2
Reactivity Mouse
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 86624 Da
Antigen Region 701-728 aa
Additional Information
Gene ID 228012
Other Names Serine/threonine-protein kinase tousled-like 1, Tousled-like kinase 1, Tlk1
Target/Specificity This Mouse Tlk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 701-728 amino acids from the C-terminal region of mouse Tlk1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Tlk1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tlk1
Function Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity).
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed in all tissues examined.
Research Areas
Citations (0)

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Background

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity).

References

Canfield, C., et al. BMC Mol. Biol. 10, 110 (2009) :
Taniwaki, T., et al. Dev. Growth Differ. 47(3):163-172(2005)
Sunavala-Dossabhoy, G., et al. BMC Mol. Biol. 6, 19 (2005) :
Cobellis, G., et al. Nucleic Acids Res. 33 (4), E44 (2005) :
Okazaki, N., et al. DNA Res. 11(3):205-218(2004)

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$ 295.00
$ 99.00
Cat# AP17323B
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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