Mouse Tlk1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8C0V0 |
Other Accession | Q9UKI8, NP_766252.2 |
Reactivity | Mouse |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 86624 Da |
Antigen Region | 701-728 aa |
Gene ID | 228012 |
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Other Names | Serine/threonine-protein kinase tousled-like 1, Tousled-like kinase 1, Tlk1 |
Target/Specificity | This Mouse Tlk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 701-728 amino acids from the C-terminal region of mouse Tlk1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Tlk1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Tlk1 |
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Function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Ubiquitously expressed in all tissues examined. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity).
References
Canfield, C., et al. BMC Mol. Biol. 10, 110 (2009) :
Taniwaki, T., et al. Dev. Growth Differ. 47(3):163-172(2005)
Sunavala-Dossabhoy, G., et al. BMC Mol. Biol. 6, 19 (2005) :
Cobellis, G., et al. Nucleic Acids Res. 33 (4), E44 (2005) :
Okazaki, N., et al. DNA Res. 11(3):205-218(2004)
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