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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   WDR68 Antibody (C-term)   

WDR68 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - WDR68 Antibody (C-term) AP17326b
    WDR68 Antibody (C-term) (Cat. #AP17326b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the WDR68 antibody detected the WDR68 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P61962
Other Accession P61963, NP_005819.3
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38926 Da
Antigen Region 285-314 aa
Additional Information
Gene ID 10238
Other Names DDB1- and CUL4-associated factor 7, WD repeat-containing protein 68, WD repeat-containing protein An11 homolog, DCAF7, HAN11, WDR68
Target/Specificity This WDR68 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the C-terminal region of human WDR68.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWDR68 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCAF7
Synonyms HAN11, WDR68
Function Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex.
Cellular Location Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm
Research Areas
Citations (0)

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Background

WDR68 is involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

References

Ritterhoff, S., et al. EMBO J. 29(22):3750-3761(2010)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Morita, K., et al. J. Dermatol. Sci. 44(1):11-20(2006)
Jin, J., et al. Mol. Cell 23(5):709-721(2006)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)

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$ 295.00
$ 99.00
Cat# AP17326b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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