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NECAB2 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NECAB2 Antibody (N-term) AP17328A
    NECAB2 Antibody (N-term) (Cat. #AP17328a) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the NECAB2 antibody detected the NECAB2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q7Z6G3
Other Accession NP_061938.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 43194 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 54550
Other Names N-terminal EF-hand calcium-binding protein 2, EF-hand calcium-binding protein 2, Neuronal calcium-binding protein 2, Synaptotagmin-interacting protein 2, Stip-2, NECAB2, EFCBP2
Target/Specificity This NECAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NECAB2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNECAB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NECAB2
Synonyms EFCBP2
Function May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:F1LQY6, ECO:0000250|UniProtKB:Q91ZP9}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1LQY6}. Cell projection, axon {ECO:0000250|UniProtKB:F1LQY6}. Cell membrane Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity) {ECO:0000250|UniProtKB:F1LQY6, ECO:0000269|PubMed:17689978, ECO:0000269|PubMed:19694902, ECO:0000269|PubMed:26843217}
Tissue Location Expressed in brain. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons and in ependymal cells (at protein level)
Research Areas
Citations (0)
citation

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Background

The specific function of this protein remains unknown.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Canela, L., et al. J. Neurochem. 111(2):555-567(2009)
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
Canela, L., et al. Mol. Cell. Neurosci. 36(1):1-12(2007)
Lim, J., et al. Cell 125(4):801-814(2006)

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$ 182.50
$ 70.00
Cat# AP17328A
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