|Application ||WB, E|
|Calculated MW||42151 Da|
|Antigen Region||142-171 aa|
|Other Names||Nucleoporin Nup43, Nup107-160 subcomplex subunit Nup43, p42, NUP43|
|Target/Specificity||This NUP43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-171 amino acids from the Central region of human NUP43.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NUP43 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.|
|Cellular Location||Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex|
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Provided below are standard protocols that you may find useful for product applications.
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).
Zuccolo, M., et al. EMBO J. 26(7):1853-1864(2007)
Glavy, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(10):3811-3816(2007)
Loiodice, I., et al. Mol. Biol. Cell 15(7):3333-3344(2004)
Le Rouzic, E., et al. J. Biol. Chem. 277(47):45091-45098(2002)
Cronshaw, J.M., et al. J. Cell Biol. 158(5):915-927(2002)
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