|Application ||WB, E|
|Other Accession||NP_001181929.1, NP_001181928.1|
|Calculated MW||39366 Da|
|Antigen Region||312-341 aa|
|Other Names||Major histocompatibility complex class I-related gene protein, MHC class I-related gene protein, Class I histocompatibility antigen-like protein, MR1|
|Target/Specificity||This MR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-341 amino acids from the C-terminal region of human MR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T- cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.|
|Cellular Location||Cell membrane; Single-pass membrane protein; Extracellular side. Endoplasmic reticulum Isoform 3: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Note=The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway|
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Provided below are standard protocols that you may find useful for product applications.
MR1 has antigen presentation function. Involved in the development and expansion of a small population of T cells expressing an invariant T cell receptor alpha chain called mucosal-associated invariant T cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therfore may be involed in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.
Gozalbo-Lopez, B., et al. Histol. Histopathol. 24(11):1439-1449(2009)
Stumpf, A.N., et al. Blood 114(17):3684-3692(2009)
Huang, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(20):8290-8295(2009)
Aldemir, H. Biochem. Biophys. Res. Commun. 366(2):328-334(2008)
Miley, M.J., et al. J. Immunol. 170(12):6090-6098(2003)
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