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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SOX7 Antibody (C-term)   

SOX7 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SOX7 Antibody (C-term) AP17335b
    SOX7 Antibody (C-term) (Cat. #AP17335b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SOX7 antibody detected the SOX7 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BT81
Other Accession P40646, NP_113627.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 42197 Da
Antigen Region 310-339 aa
Additional Information
Gene ID 83595
Other Names Transcription factor SOX-7, SOX7
Target/Specificity This SOX7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the C-terminal region of human SOX7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOX7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX7
Function Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}. Cytoplasm
Tissue Location Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.
Research Areas
Citations (0)

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This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway.


Zhang, Y., et al. Cancer Lett. 277(1):29-37(2009)
Semb, H. Cell Stem Cell 3(4):355-356(2008)
Guo, L., et al. Mol. Cancer Res. 6(9):1421-1430(2008)
Seguin, C.A., et al. Cell Stem Cell 3(2):182-195(2008)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)

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$ 295.00
$ 99.00
Cat# AP17335b
(40 western blots)
Availability: In Stock
Bulk Size
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