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NARF Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NARF Antibody (Center) AP17343c
    NARF Antibody (Center) (Cat. #AP17343c) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the NARF antibody detected the NARF protein (arrow).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UHQ1
Other Accession NP_001033707.1, NP_001077077.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 51156 Da
Antigen Region 134-160 aa
Additional Information
Gene ID 26502
Other Names Nuclear prelamin A recognition factor, Iron-only hydrogenase-like protein 2, IOP2, NARF
Target/Specificity This NARF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-160 amino acids from the Central region of human NARF.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNARF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NARF
Cellular Location Nucleus.
Tissue Location Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.
Research Areas
Citations (0)
citation

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Background

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Moller-Krull, M., et al. J. Mol. Biol. 382(3):601-609(2008)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
Lattanzi, G., et al. J. Cell. Biochem. 102(5):1149-1159(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)

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$ 182.50
$ 70.00
Cat# AP17343c
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