|Application ||WB, E|
|Other Accession||NP_001164120.1, NP_001164121.1|
|Calculated MW||83065 Da|
|Antigen Region||639-665 aa|
|Other Names||Ribosomal biogenesis protein LAS1L, Protein LAS1 homolog, LAS1L|
|Target/Specificity||This LAS1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 639-665 amino acids from the C-terminal region of human LAS1L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LAS1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.|
|Cellular Location||Nucleus, nucleolus Nucleus, nucleoplasm. Cytoplasm Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export|
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Provided below are standard protocols that you may find useful for product applications.
The function of LAS1L has not been determined.
Castle, C.D., et al. Mol. Cell. Biol. 30(18):4404-4414(2010)
Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)
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