|Application ||WB, E|
|Calculated MW||30433 Da|
|Antigen Region||175-203 aa|
|Other Names||Calcium-binding protein 4, CaBP4, CABP4|
|Target/Specificity||This CABP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-203 amino acids from the C-terminal region of human CABP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CABP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).|
|Cellular Location||Cytoplasm. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.|
|Tissue Location||Expressed in retina and in the inner hair cells (IHC) of the cochlea|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B.
Aldahmesh, M.A., et al. Mol. Vis. 16, 207-212 (2010) :
Littink, K.W., et al. Invest. Ophthalmol. Vis. Sci. 50(5):2344-2350(2009)
Zeitz, C., et al. Am. J. Hum. Genet. 79(4):657-667(2006)
Taylor, T.D., et al. Nature 440(7083):497-500(2006)
Haeseleer, F., et al. Nat. Neurosci. 7(10):1079-1087(2004)
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