|Application ||WB, E|
|Other Accession||Q69ZF8, NP_001138889.1, NP_060603.2|
|Calculated MW||62541 Da|
|Antigen Region||4-32 aa|
|Other Names||E3 ubiquitin-protein ligase MSL2, 632-, Male-specific lethal 2-like 1, MSL2-like 1, Male-specific lethal-2 homolog, MSL-2, Male-specific lethal-2 homolog 1, RING finger protein 184, MSL2, KIAA1585, MSL2L1, RNF184|
|Target/Specificity||This MSL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human MSL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MSL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1585, MSL2L1, RNF184|
|Function||Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.|
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Provided below are standard protocols that you may find useful for product applications.
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure.
Dehghan, A., et al. Circ Cardiovasc Genet 2(2):125-133(2009)
Mendjan, S., et al. Mol. Cell 21(6):811-823(2006)
Smith, E.R., et al. Mol. Cell. Biol. 25(21):9175-9188(2005)
Marin, I. J. Mol. Evol. 56(5):527-539(2003)
Lyman, L.M., et al. Genetics 147(4):1743-1753(1997)
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