|Application ||WB, E|
|Other Accession||Q8VHH5, NP_001036000.1, NP_114152.3|
|Calculated MW||95044 Da|
|Antigen Region||190-217 aa|
|Other Names||Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3, AGAP-3, CRAM-associated GTPase, CRAG, Centaurin-gamma-3, Cnt-g3, MR1-interacting protein, MRIP-1, AGAP3, CENTG3|
|Target/Specificity||This AGAP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-217 amino acids from the N-terminal region of human AGAP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AGAP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.|
|Cellular Location||Cytoplasm. Note=In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Qin, Q., et al. J. Cell Biol. 172(4):497-504(2006)
Meurer, S., et al. J. Biol. Chem. 279(47):49346-49354(2004)
Surks, H.K., et al. J. Biol. Chem. 278(51):51484-51493(2003)
Xia, C., et al. Mol. Cell. Biol. 23(7):2476-2488(2003)
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