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SAFB Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP17362a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP17362a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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SAFB Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | Q15424 |
| Other Accession | NP_002958.2 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 102642 Da |
SAFB Antibody (N-term) - Additional info | |
| Gene ID 6294 | |
| Other Names SAFB; HET; HAP; SAFB1; Scaffold attachment factor B1; HSP27 estrogen response element-TATA box-binding protein | |
| Target/Specificity This SAFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-94 amino acids from the N-terminal region of human SAFB. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SAFB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SAFB Antibody (N-term) - Protein Information | |
| Name SAFB | |
| Synonyms HAP, HET, SAFB1 | |
| Function Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation | |
| Cellular Location Nucleus. | |
| Tissue Location Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines | |
SAFB Antibody (N-term) - Related products
SAFB Antibody (N-term) - Application data
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SAFB Antibody (N-term) (Cat. #AP17362a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SAFB antibody detected the SAFB protein (arrow).
SAFB Antibody (N-term) - Research Areas
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BACKGROUND
This gene encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. This encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis.
REFERENCES
Hammerich-Hille, S., et al. Breast Cancer Res. Treat. 121(2):503-509(2010) Hammerich-Hille, S., et al. J. Biol. Chem. 285(6):3608-3616(2010) Tsianou, D., et al. FEBS J. 276(18):5212-5227(2009) Chen, H., et al. Endocrinology 150(5):2429-2435(2009) Bergman, A., et al. BMC Med. Genet. 9, 108 (2008) :
