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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NET1 Antibody (Center)   

NET1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NET1 Antibody (Center) AP17382C
    NET1 Antibody (Center) (Cat. #AP17382c) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the NET1 antibody detected the NET1 protein (arrow).
  • WB - NET1 Antibody (Center) AP17382C
    NET1 Antibody (Center) (Cat. #AP17382c) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the NET1 antibody detected the NET1 protein (arrow).
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q7Z628
Other Accession NP_001040625.1, NP_005854.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 67740 Da
Antigen Region 356-385 aa
Additional Information
Gene ID 10276
Other Names Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8, NET1, ARHGEF8
Target/Specificity This NET1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 356-385 amino acids from the Central region of human NET1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNET1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NET1
Synonyms ARHGEF8
Function Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed.
Research Areas
Citations ( 0 )

Background

NET1 acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway (By similarity).

References

Lee, J., et al. J. Biol. Chem. 285(34):26618-26627(2010)
Carr, H.S., et al. J. Biol. Chem. 284(36):24269-24280(2009)
Gilcrease, M.Z., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):80-86(2009)
Murray, D., et al. Br. J. Cancer 99(8):1322-1329(2008)
Guerra, L., et al. PLoS ONE 3 (5), E2254 (2008) :

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$ 295.00
$ 99.00
Cat# AP17382C
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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