- CITATIONS: 1
|Application ||WB, E|
|Other Accession||NP_001040625.1, NP_005854.2|
|Calculated MW||67740 Da|
|Antigen Region||356-385 aa|
|Other Names||Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8, NET1, ARHGEF8|
|Target/Specificity||This NET1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 356-385 amino acids from the Central region of human NET1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NET1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed.|
Provided below are standard protocols that you may find useful for product applications.
NET1 acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway (By similarity).
Lee, J., et al. J. Biol. Chem. 285(34):26618-26627(2010)
Carr, H.S., et al. J. Biol. Chem. 284(36):24269-24280(2009)
Gilcrease, M.Z., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):80-86(2009)
Murray, D., et al. Br. J. Cancer 99(8):1322-1329(2008)
Guerra, L., et al. PLoS ONE 3 (5), E2254 (2008) :
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