|Application ||WB, E|
|Other Accession||O55057, Q95142, NP_002592.1|
|Calculated MW||17420 Da|
|Antigen Region||26-55 aa|
|Other Names||Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase subunit delta, GMP-PDE delta, Protein p17, PDE6D, PDED|
|Target/Specificity||This PDE6D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the Central region of human PDE6D.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE6D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, cilium basal body|
|Tissue Location||Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.|
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Provided below are standard protocols that you may find useful for product applications.
Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation.
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Wilson, S.J., et al. J. Biol. Chem. 281(17):11780-11786(2006)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Hanzal-Bayer, M., et al. EMBO J. 21(9):2095-2106(2002)
Nancy, V., et al. J. Biol. Chem. 277(17):15076-15084(2002)
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