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PDE6D Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PDE6D Antibody (Center) AP17384c
    PDE6D Antibody (Center) (Cat. #AP17384c) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the PDE6D antibody detected the PDE6D protein (arrow).
  • WB - PDE6D Antibody (Center) AP17384c
    PDE6D Antibody (Center) (Cat. #AP17384c) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the PDE6D antibody detected the PDE6D protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43924
Other Accession O55057, Q95142, NP_002592.1
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 17420 Da
Antigen Region 26-55 aa
Additional Information
Gene ID 5147
Other Names Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase subunit delta, GMP-PDE delta, Protein p17, PDE6D, PDED
Target/Specificity This PDE6D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the Central region of human PDE6D.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDE6D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE6D
Synonyms PDED
Function Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).
Cellular Location Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, cilium basal body
Tissue Location Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.
Research Areas
Citations (0)

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Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation.


Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Wilson, S.J., et al. J. Biol. Chem. 281(17):11780-11786(2006)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Hanzal-Bayer, M., et al. EMBO J. 21(9):2095-2106(2002)
Nancy, V., et al. J. Biol. Chem. 277(17):15076-15084(2002)

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Cat# AP17384c
(40 western blots)
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