|Application ||WB, E|
|Other Accession||P12075, Q5S3G4, P19536, P00428, NP_001853.2|
|Reactivity||Human, Mouse, Rat|
|Predicted||Bovine, Mouse, Pig, Rat|
|Calculated MW||13696 Da|
|Antigen Region||21-49 aa|
|Other Names||Cytochrome c oxidase subunit 5B, mitochondrial, Cytochrome c oxidase polypeptide Vb, COX5B|
|Target/Specificity||This COX5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the Central region of human COX5B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COX5B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.|
|Cellular Location||Mitochondrion inner membrane.|
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Provided below are standard protocols that you may find useful for product applications.
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme.
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Chen, Z.X., et al. Cell Death Differ. 17(3):408-420(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Beauchemin, A.M., et al. Brain Res. Bull. 56 (3-4), 285-297 (2001) :
Wu, H., et al. J. Biol. Chem. 275(42):32491-32498(2000)
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