|Application ||WB, E|
|Calculated MW||21615 Da|
|Antigen Region||70-99 aa|
|Other Names||PRA1 family protein 3, ADP-ribosylation factor-like protein 6-interacting protein 5, ARL-6-interacting protein 5, Aip-5, Cytoskeleton-related vitamin A-responsive protein, Dermal papilla-derived protein 11, GTRAP3-18, Glutamate transporter EAAC1-interacting protein, JM5, Prenylated Rab acceptor protein 2, Protein JWa, Putative MAPK-activating protein PM27, ARL6IP5, DERP11, JWA, PRA2, PRAF3|
|Target/Specificity||This ARL6IP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-99 amino acids from the Central region of human ARL6IP5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARL6IP5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DERP11, JWA, PRA2, PRAF3|
|Function||Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein Cytoplasm. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules (By similarity)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.
Edenberg, H.J., et al. Alcohol. Clin. Exp. Res. 34(5):840-852(2010)
Akiduki, S., et al. J. Biol. Chem. 283(46):31323-31332(2008)
Ruggiero, A.M., et al. J. Biol. Chem. 283(10):6175-6183(2008)
Watabe, M., et al. Mol. Pharmacol. 72(5):1103-1110(2007)
Zhu, Y.J., et al. J. Toxicol. Environ. Health Part A 70(11):895-900(2007)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.