|Application ||WB, E|
|Other Accession||NP_995309.2, NP_001160010.1|
|Calculated MW||10792 Da|
|Antigen Region||19-47 aa|
|Other Names||Leukocyte-specific transcript 1 protein, Protein B144, LST1, B144|
|Target/Specificity||This LST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the Central region of human LST1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LST1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.|
|Cellular Location||Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein Endomembrane system; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm|
|Tissue Location||Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain|
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Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Man, M., et al. J Clin Pharmacol 50(8):929-940(2010)
Rojas, J., et al. Ophthalmology (2010) In press :
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :
Ovsyannikova, I.G., et al. PLoS ONE 5 (7), E11806 (2010) :
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