|Application ||WB, E|
|Calculated MW||25673 Da|
|Antigen Region||193-222 aa|
|Other Names||Steroid receptor RNA activator 1, Steroid receptor RNA activator protein, SRAP, SRA1 (HGNC:11281)|
|Target/Specificity||This SRA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-222 amino acids from the C-terminal region of human SRA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SRA1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up- regulated in human tumors of the breast, ovary, and uterus|
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Provided below are standard protocols that you may find useful for product applications.
This gene is involved in transcriptional coactivation by steroid receptors. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.
Yao, H., et al. Genes Dev. 24(22):2543-2555(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Beauvillain, C., et al. J. Hepatol. 52(5):644-651(2010)
Foulds, C.E., et al. Mol. Endocrinol. 24(5):1090-1105(2010)
Chooniedass-Kothari, S., et al. FEBS Lett. 584(6):1174-1180(2010)
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