|Application ||WB, E|
|Other Accession||NP_001159648.1, NP_001159647.1|
|Calculated MW||34918 Da|
|Antigen Region||2-5 aa|
|Other Names||Homeobox protein Nkx-25, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, NKX2-5, CSX, NKX25, NKX2E|
|Target/Specificity||This NKX2-5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-111 amino acids from the Central region of human NKX2-5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NKX2-5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CSX, NKX2.5, NKX2E|
|Function||Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development.|
|Tissue Location||Expressed only in the heart.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
De Luca, A., et al. Clin. Genet. (2010) In press :
Stallmeyer, B., et al. Clin. Genet. (2010) In press :
Narumi, S., et al. J. Clin. Endocrinol. Metab. 95(4):1981-1985(2010)
Joubert, B.R., et al. Genome Med 2 (3), 17 (2010) :
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