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>   home   >   Products   >   Primary Antibodies   >   SNF8 Antibody (N-term)   

SNF8 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SNF8 Antibody (N-term) AP17410a
    SNF8 Antibody (N-term) (Cat. #AP17410a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SNF8 antibody detected the SNF8 protein (arrow).
  • WB - SNF8 Antibody (N-term) AP17410a
    Western blot analysis of SNF8 (arrow) using rabbit polyclonal SNF8 Antibody (N-term) (Cat. #AP17410a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SNF8 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96H20
Other Accession Q5RK19, Q9CZ28, NP_009172.2
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28864 Da
Antigen Region 37-65 aa
Additional Information
Gene ID 11267
Other Names Vacuolar-sorting protein SNF8, ELL-associated protein of 30 kDa, ESCRT-II complex subunit VPS22, hVps22, SNF8, EAP30
Target/Specificity This SNF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human SNF8.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSNF8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNF8
Synonyms EAP30
Function Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.
Cellular Location Cytoplasm. Endosome membrane. Nucleus. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation
Citations (0)

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SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).


Malerod, L., et al. Traffic 8(11):1617-1629(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Langelier, C., et al. J. Virol. 80(19):9465-9480(2006)
Bowers, K., et al. J. Biol. Chem. 281(8):5094-5105(2006)
Slagsvold, T., et al. J. Biol. Chem. 280(20):19600-19606(2005)

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$ 295.00
$ 99.00
Cat# AP17410a
(40 western blots)
Availability: In Stock
Bulk Size
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