|Application ||WB, E|
|Calculated MW||63955 Da|
|Antigen Region||38-67 aa|
|Other Names||Tripartite motif-containing protein 16, Estrogen-responsive B box protein, TRIM16, EBBP|
|Target/Specificity||This TRIM16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-67 amino acids from the N-terminal region of human TRIM16.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM16 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the regulation of keratinocyte differentiation.|
|Tissue Location||Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes|
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Provided below are standard protocols that you may find useful for product applications.
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.
Raif, A., et al. Cancer Lett. 277(1):82-90(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Munding, C., et al. Cell Death Differ. 13(11):1938-1949(2006)
Cheung, B.B., et al. J. Biol. Chem. 281(26):18246-18256(2006)
Gwinn, M.R., et al. Environ. Health Perspect. 113(8):1046-1051(2005)
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