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TRIM16 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95361 |
| Other Accession | NP_006461.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 63955 Da |
| Antigen Region | 38-67 aa |
| Gene ID | 10626 |
|---|---|
| Other Names | Tripartite motif-containing protein 16, Estrogen-responsive B box protein, TRIM16, EBBP |
| Target/Specificity | This TRIM16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-67 amino acids from the N-terminal region of human TRIM16. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM16 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM16 |
|---|---|
| Synonyms | EBBP |
| Function | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.
References
Raif, A., et al. Cancer Lett. 277(1):82-90(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Munding, C., et al. Cell Death Differ. 13(11):1938-1949(2006)
Cheung, B.B., et al. J. Biol. Chem. 281(26):18246-18256(2006)
Gwinn, M.R., et al. Environ. Health Perspect. 113(8):1046-1051(2005)
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