|Application ||WB, E|
|Calculated MW||18546 Da|
|Antigen Region||103-132 aa|
|Other Names||Lymphocyte antigen 96, Ly-96, ESOP-1, Protein MD-2, LY96, ESOP1, MD2|
|Target/Specificity||This LY96 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the C-terminal region of human LY96.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LY96 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram- positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).|
|Cellular Location||Secreted, extracellular space. Secreted. Note=Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms.
Meng, J., et al. J. Biol. Chem. 285(36):27935-27943(2010)
Gray, P., et al. J. Immunol. 184(11):6359-6366(2010)
Salvesen, B., et al. Mol. Immunol. 47(6):1226-1234(2010)
Ohnishi, T., et al. Microbiol. Immunol. 54(2):74-80(2010)
Xue, Y., et al. Genet. Mol. Res. 9(3):1584-1590(2010)
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