|Application ||WB, E|
|Other Accession||Q2PFX1, Q5BIP2, NP_006198.1|
|Calculated MW||41861 Da|
|Antigen Region||16-44 aa|
|Other Names||Platelet-derived growth factor receptor-like protein, PDGFR-like protein, PDGF receptor beta-like tumor suppressor, PDGFRL, PRLTS|
|Target/Specificity||This PDGFRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-44 amino acids from the N-terminal region of human PDGFRL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDGFRL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in colon, lung and liver.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Guo, F.J., et al. World J. Gastroenterol. 16(12):1465-1472(2010)
Riker, A.I., et al. BMC Med Genomics 1, 13 (2008) :
Xu, M., et al. BMC Genomics 9 SUPPL 1, S12 (2008) :
Seitz, S., et al. Genes Chromosomes Cancer 45(6):612-627(2006)
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