|Application ||WB, E|
|Other Accession||Q9R0L7, NP_055186.2|
|Calculated MW||71649 Da|
|Antigen Region||485-512 aa|
|Other Names||A-kinase anchor protein 8-like, AKAP8-like protein, Helicase A-binding protein 95, HAP95, Homologous to AKAP95 protein, HA95, Neighbor of A-kinase-anchoring protein 95, Neighbor of AKAP95, AKAP8L, NAKAP, NAKAP95|
|Target/Specificity||This AKAP8L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 485-512 amino acids from the C-terminal region of human AKAP8L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AKAP8L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta.|
|Cellular Location||Nucleus matrix. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix (By similarity). Nuclear at steady state but shuttles between the nucleus and cytoplasm Associated with the nuclear matrix.|
|Tissue Location||Expressed in the brain cortex (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
AKAP8L could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta.
Sugiura, T., et al. Exp. Cell Res. 314(7):1519-1528(2008)
Kvissel, A.K., et al. Exp. Cell Res. 313(13):2795-2809(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Sayer, J.A., et al. Neuromolecular Med. 7(4):297-310(2005)
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