|Application ||WB, E|
|Other Accession||P61227, P61226, Q06AU2, NP_002877.2|
|Predicted||Pig, Mouse, Rat|
|Calculated MW||20504 Da|
|Antigen Region||102-129 aa|
|Other Names||Ras-related protein Rap-2b, RAP2B|
|Target/Specificity||This RAP2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-129 amino acids from the Central region of human RAP2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAP2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.|
|Cellular Location||Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood cells-released vesicles|
|Tissue Location||Expressed in red blood cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Martins-de-Souza, D., et al. J Psychiatr Res (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Canobbio, I., et al. Cell. Signal. 20(9):1662-1670(2008)
Liu, Y., et al. Lung Cancer 56(3):307-317(2007)
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