MYOZ2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9NPC6 |
Other Accession | Q9JJW5, Q5E9V3, NP_057683.1 |
Reactivity | Human |
Predicted | Bovine, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 29898 Da |
Antigen Region | 43-71 aa |
Gene ID | 51778 |
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Other Names | Myozenin-2, Calsarcin-1, FATZ-related protein 2, MYOZ2 (HGNC:1330) |
Target/Specificity | This MYOZ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-71 amino acids from the N-terminal region of human MYOZ2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MYOZ2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MYOZ2 (HGNC:1330) |
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Function | Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
Cellular Location | Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. |
Tissue Location | Expressed specifically in heart and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MYOZ2 myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
References
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)
Aurino, S., et al. Acta Myol 27, 90-97 (2008) :
Posch, M.G., et al. Med. Sci. Monit. 14 (7), CR372-CR374 (2008) :
Posch, M.G., et al. Mol. Genet. Metab. 91(2):207-208(2007)
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