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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   QPCT Antibody (C-term)   

QPCT Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - QPCT Antibody (C-term) AP17434b
    QPCT Antibody (C-term) (Cat. #AP17434b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the QPCT antibody detected the QPCT protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16769
Other Accession NP_036545.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 40877 Da
Antigen Region 315-343 aa
Additional Information
Gene ID 25797
Other Names Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase, QC, sQC, Glutaminyl-tRNA cyclotransferase, Glutamyl cyclase, EC, QPCT
Target/Specificity This QPCT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-343 amino acids from the C-terminal region of human QPCT.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsQPCT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
Cellular Location Secreted.
Research Areas
Citations (0)

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This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.


Morawski, M., et al. Acta Neuropathol. 120(2):195-207(2010)
Stephan, A., et al. FEBS J. 276(22):6522-6536(2009)
Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)
Calvaresi, M., et al. Proteins 73(3):527-538(2008)
Cynis, H., et al. J. Mol. Biol. 379(5):966-980(2008)

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Cat# AP17434b
(40 western blots)
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