|Application ||WB, E|
|Other Accession||Q69ZX8, NP_055760.1|
|Calculated MW||77802 Da|
|Antigen Region||613-641 aa|
|Other Names||Actin-binding LIM protein 3, abLIM-3, Actin-binding LIM protein family member 3, ABLIM3, KIAA0843|
|Target/Specificity||This ABLIM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-641 amino acids from the C-terminal region of human ABLIM3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABLIM3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.|
|Tissue Location||Expressed predominantly in heart and brain.|
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Provided below are standard protocols that you may find useful for product applications.
The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer (Krupp et al., 2006 [PubMed 16328021]).
Barrientos, T., et al. J. Biol. Chem. 282(11):8393-8403(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Krupp, M., et al. Int. J. Mol. Med. 17(1):129-133(2006)
Zheng, B., et al. Biochim. Biophys. Acta 1690(1):1-10(2004)
Yamada, S., et al. Oncogene 23(35):5901-5911(2004)
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